Inhibits PDE-5, increasing cyclic guanosine monophosphate cGMP to allow smooth-muscle relaxation Metabolized in liver by CYP3A4 and (in minor amounts) CYP2C9 Metabolites: N-desmethyl metabolite (active; possesses 50% of sildenafil's PDE-5-inhibiting activity) Half-life: Parent drug, 3-4 hr; active metabolite, 10-70 min Take as needed, about 1 hr before sexual activity; however, may be taken anywhere from 30 minutes to 4 hr before sexual activity Maximum recommended dosing frequency is once daily Place oral film directly onto tongue where it will disintegrate and can then be swallowed with saliva without need for water or other liquids Take as needed, about 1 hr before sexual activity; however, may be taken anywhere from 30 minutes to 4 hr before sexual activity Maximum recommended dosing frequency is once daily Reconstitution of oral suspensionReconstitute bottle contents with water (total volume of 90 mL [60 mL followed by 30 mL])Refer to prescribing information for detailed instructionsDo not mix with any other medication or additional flavoring agent Reconstitute bottle contents with water (total volume of 90 mL [60 mL followed by 30 mL]) Refer to prescribing information for detailed instructions Do not mix with any other medication or additional flavoring agent Store at controlled room temperature 20-25°C (68-77°F) Excursions permitted to 15-30°C (59-86°F) Store <30°C (86°F) or in a refrigerator between 2-8°C (36-46°F) Discard unused oral suspension after 60 days Adding plans allows you to compare formulary status to other drugs in the same class.

What other information should I know?

Sildenafil for oral suspension at 10 mg/mL (Revatio) is commercially available with a beyond-use date of 60 days after reconstitution. One study involved compounded sildenafil citrate in a citrate-buffered solution (0.1 M, pH 4) and either a syrup excipient (resulting in a suspension) or a sugar-free syrup excipient (resulting in a solution); both had pH values of approximately 4.2. Both sildenafil tablets lp 100 mg the suspension and the solution were slightly pink and fruit-flavored. The suspension demonstrated stability for 91 days at both 4°C and 25°C; however, the solution was stable only for 30 days, possibly related to a nonredispersible sediment at the bottom of the container.3 A study by Nahata and colleagues that involved sildenafil citrate tablets (Revatio 20 mg) with a mixture of 1:1 Ora-Sweet and Ora-Plus at 2.5 mg/mL and pH 4.5-4.7 demonstrated stability of 91 days at both 4°C and 25°C. Also studied was a mixture of 1:7 (1% methyl cellulose:simple syrup) at pH 5.1 to 4.9 that also demonstrated stability of 91 days at both 4°C and 25°C.4 Sildenafil citrate (C22H30N6O4S.C6H8O7, MW 666.70) occurs as a white to off-white, crystalline powder that is soluble 3.5 mg/mL in water.

More common

It is formulated as tablets equivalent to 25 mg, 50 mg, and 100 mg of sildenafil for oral administration. The tablets also contain microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, lactose, triacetin, and FD&C Blue #2 Aluminum Lake.6,7 Ora-Plus is an oral suspending vehicle that accepts dilution of up to 50% or more with water, flavoring agents, or syrups while still retaining its suspending properties. It has a pH of approximately 4.2 and an osmolality of about 230 mOsm/kg. It is a thixotropic vehicle with a viscosity of approximately 1,000 cps at 25°C. Ora-Plus contains purified water, microcrystalline cellulose, sodium carboxymethyl cellulose, xanthan gum, carrageenan, sodium phosphate, and citric acid as buffering agents; simethicone as an antifoaming agent; and potassium sorbate and methylparaben as preservatives.8 Ora-Sweet syrup vehicle is a flavoring vehicle for oral extemporaneous preparations.

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It is flavored with a citrus-berry flavor blend and contains glycerin and sorbitol to prevent cap lock, a problem associated with many syrups. It is buffered to a pH of approximately 4.2 and it has an osmolality of about 3,240 mOsm/kg. To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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View the formulary and any restrictions for each plan. Manage and view all your plans together – even plans in different states.

Detection in biological fluids

Diabetes-related impotence in the elderly

Compare formulary status to other drugs in the same class. Access your plan list on any device – mobile or desktop. (Liquid Formulation of PDE5 Inhibitor for Erectile Dysfunction and Vascular Support) Sildenafil Drops offer a liquid, titratable formulation of the well-known PDE5 inhibitor used to treat erectile dysfunction (ED), as well as select off-label vascular conditions. Each 30 mL bottle contains a total of 100 mg of sildenafil citrate, delivered sildenafil uk price in a drop-based dosing format that allows for precise micro-dosing, rapid absorption, and convenient administration—especially for individuals who prefer not to take tablets or who require flexible titration. Compounded by prescription, this formulation is ideal for patients seeking a customized dosing solution to support sexual performance, vascular responsiveness, and in some cases, exercise tolerance or pulmonary vascular conditions under clinical supervision.

Full Text Sources

Concentration: 100 mg total per 30 mL Use: Erectile dysfunction, vascular enhancement, off-label support for pulmonary conditions Storage: Room temperature (20–25°C); refrigerate if directed Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by enhancing the effects of nitric oxide, a natural vasodilator, in vascular smooth muscle. Support sexual arousal response via increased penile blood flow Improve endothelial function and vascular tone in specific medical conditions The drop-based formulation provides a non-tablet alternative, allowing for more individualized and dynamic use, especially in patients with: Preference for rapid titration with fewer side effects Sildenafil inhibits PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP). Improved blood flow to the corpus cavernosum of the penis Enhanced erection quality, rigidity, and duration during sexual stimulation Lowered pulmonary vascular resistance (off-label applications) This action requires sexual arousal to be effective and does not induce spontaneous erections. Especially effective in men with mild-to-moderate ED, age-related vascular decline, or performance anxiety Allows dose customization based on sensitivity or side-effect profile Off-label use in some protocols for pulmonary hypertension, Raynaud’s syndrome, or vascular insufficiency May aid in exercise performance in certain cardiac rehabilitation settings (by prescription only) Integrated into biohacking or anti-aging programs focused on vascular optimization and intimacy health Typical ED Starting Dose: 5–20 mg (1.5–6 mL depending on compounding instructions) taken orally 30–60 minutes before sexual activity Adjustment: May be increased or decreased based on efficacy and tolerability Administration: Use calibrated dropper or oral syringe for accurate measurement Always follow compounding pharmacy or prescriber-specific instructions, as concentration may vary slightly by batch. Sildenafil is well tolerated, especially in liquid form where smaller doses can be administered and titrated. Compare formulary status to other drugs in the same class.

What side effects can this medication cause?

Access your plan list on any device – mobile or desktop. (Liquid Formulation of PDE5 Inhibitor for Erectile Dysfunction and Vascular Support) Sildenafil Drops offer a liquid, titratable formulation of the well-known PDE5 inhibitor used to treat erectile dysfunction (ED), as well as select off-label vascular conditions. Each 30 mL bottle contains a total of 100 mg of sildenafil citrate, delivered sildenafil uk price in a drop-based dosing format that allows for precise micro-dosing, rapid absorption, and convenient administration—especially for individuals who prefer not to take tablets or who require flexible titration. Compounded by prescription, this formulation is ideal for patients seeking a customized dosing solution to support sexual performance, vascular responsiveness, and in some cases, exercise tolerance or pulmonary vascular conditions under clinical supervision. Concentration: 100 mg total per 30 mL Use: Erectile dysfunction, vascular enhancement, off-label support for pulmonary conditions Storage: Room temperature (20–25°C); refrigerate if directed Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by enhancing the effects of nitric oxide, a natural vasodilator, in vascular smooth muscle. Support sexual arousal response via increased penile blood flow Improve endothelial function and vascular tone in specific medical conditions The drop-based formulation provides a non-tablet alternative, allowing for more individualized and dynamic use, especially in patients with: Preference for rapid titration with fewer side effects Sildenafil inhibits PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP). Improved blood flow to the corpus cavernosum of the penis Enhanced erection quality, rigidity, and duration during sexual stimulation Lowered pulmonary vascular resistance (off-label applications) This action requires sexual arousal to be effective and does not induce spontaneous erections. Especially effective in men with mild-to-moderate ED, age-related vascular decline, or performance anxiety Allows dose customization based on sensitivity or side-effect profile Off-label use in some protocols for pulmonary hypertension, Raynaud’s syndrome, or vascular insufficiency May aid in exercise performance in certain cardiac rehabilitation settings (by prescription only) Integrated into biohacking or anti-aging programs focused on vascular optimization and intimacy health Typical ED Starting Dose: 5–20 mg (1.5–6 mL depending on compounding instructions) taken orally 30–60 minutes before sexual activity Adjustment: May be increased or decreased based on efficacy and tolerability Administration: Use calibrated dropper or oral syringe for accurate measurement Always follow compounding pharmacy or prescriber-specific instructions, as concentration may vary slightly by batch. Sildenafil is well tolerated, especially in liquid form where smaller doses can be administered and titrated. Visual disturbances (blue-tinged vision, light sensitivity) These effects are dose-dependent and generally mild. Hypotension when combined with nitrates or alpha-blockers Cardiovascular events in high-risk patients (rare with appropriate screening) Taking nitrate medications (risk of severe hypotension) History of retinal disorders (e.g., NAION) Known allergy to sildenafil or similar compounds Use caution in patients with liver/kidney disease or those on multiple antihypertensives. Store in a cool, dry place (room temperature or as labeled) Shake well before each use if suspension-based Use within 30–60 days of opening or per pharmacy guidance Faster absorption and onset than traditional tablets for some users Easier administration for those with pill aversion or dysphagia Supports personalized ED therapy or off-label vascular care Custom-compounded for purity and consistent concentration Sildenafil Drops – 100 mg in 30 mL Oral Liquid provide a convenient, precisely dosed alternative to traditional ED medications. Whether used to manage erectile dysfunction, support vascular function, or enhance sexual wellness, this formulation offers flexibility, discretion, and clinical-grade reliability. Custom-compounded for safety and absorption, it’s an ideal option for patients seeking personalized performance enhancement under medical guidance. Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Mix 50 mL of Ora-Plus with 50 mL of Ora-Sweet for use as the vehicle in this preparation.

Common side effects include headache, flushing, and nasal congestion.
Serious side effects are rare but can include vision changes and priapism.
Report any severe reactions to your doctor immediately.

Obtain the required number of sildenafil citrate tablets or the required quantity of powder and place in a mortar.

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Visual disturbances (blue-tinged vision, light sensitivity) These effects are dose-dependent and generally mild. Hypotension when combined with nitrates or alpha-blockers Cardiovascular events in high-risk patients (rare with appropriate screening) Taking nitrate medications (risk of severe hypotension) History of retinal disorders (e.g., NAION) Known allergy to sildenafil or similar compounds Use caution in patients with liver/kidney disease or those on multiple antihypertensives. Store in a cool, dry place (room temperature or as labeled) Shake well before each use if suspension-based Use within 30–60 days of opening or per pharmacy guidance Faster absorption and onset than traditional tablets for some users Easier administration for those with pill aversion or dysphagia Supports personalized ED therapy or off-label vascular care Custom-compounded for purity and consistent concentration Sildenafil Drops – 100 mg in 30 mL Oral Liquid provide a convenient, precisely dosed alternative to traditional ED medications. Whether used to manage erectile dysfunction, support vascular function, or enhance sexual wellness, this formulation offers flexibility, discretion, and clinical-grade reliability. Custom-compounded for safety and absorption, it’s an ideal option for patients seeking personalized performance enhancement under medical guidance.

Other Interactions

Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Mix 50 mL of Ora-Plus with 50 mL of Ora-Sweet for use as the vehicle in this preparation. Obtain the required number of sildenafil citrate tablets or the required quantity of powder and place in a mortar. Pulverize the tablets, if used, to a fine powder. Add a small quantity of the Ora-Plus:Ora-Sweet mixture and mix to a smooth paste.

Mechanism of Action

Geometrically, add the pfizer sildenafil 100 remainder of the Ora-Plus:Ora-Sweet mixture to final volume and mix well. Use: Sildenafil citrate oral liquid has been used to treat pediatric pulmonary arterial hypertension in children in whom the risk-benefit profile of sildenafil is deemed acceptable. Packaging: Package in tight, light-resistant containers.1 Labeling: Keep out of reach of children. Stability: A beyond-use date of up to 91 days may be used for this preparation.1-4 Quality Control: Quality-control assessment can include weight/volume, pH, specific gravity, active drug assay, color, rheologic properties/pourability, physical observation, and physical stability (discoloration, foreign materials, gas formation, mold growth).5 Discussion: A number of stability studies have been conducted on oral liquid formulations of sildenafil for pediatric use. From these, it appears that sildenafil is relatively stable in vehicles, with an acidic pH around 4 to 5. Pulverize the tablets, if used, to a fine powder. Add a small quantity of the Ora-Plus:Ora-Sweet mixture and mix to a smooth paste. Geometrically, add the pfizer sildenafil 100 remainder of the Ora-Plus:Ora-Sweet mixture to final volume and mix well.

Some men may experience minor flushing after taking sildenafil.
If an adverse reaction occurs, stop medication and contact your doctor.
Be aware of possible symptoms like sudden vision loss.

Use: Sildenafil citrate oral liquid has been used to treat pediatric pulmonary arterial hypertension in children in whom the risk-benefit profile of sildenafil is deemed acceptable. Packaging: Package in tight, light-resistant containers.1 Labeling: Keep out of reach of children. Stability: A beyond-use date of up to 91 days may be used for this preparation.1-4 Quality Control: Quality-control assessment can include weight/volume, pH, specific gravity, active drug assay, color, rheologic properties/pourability, physical observation, and physical stability (discoloration, foreign materials, gas formation, mold growth).5 Discussion: A number of stability studies have been conducted on oral liquid formulations of sildenafil for pediatric use. From these, it appears that sildenafil is relatively stable in vehicles, with an acidic pH around 4 to 5. Sildenafil for oral suspension at 10 mg/mL (Revatio) is commercially available with a beyond-use date of 60 days after reconstitution. One study involved compounded sildenafil citrate in a citrate-buffered solution (0.1 M, pH 4) and either a syrup excipient (resulting in a suspension) or a sugar-free syrup excipient (resulting in a solution); both had pH values of approximately 4.2.

Medication Type	Potential Interaction	Effect	Notes
Nitrates	Severe hypotension	Dangerous drop in blood pressure	Absolute contraindication
Alpha-blockers	Enhanced hypotensive effect	Blood pressure may drop too low	Use with caution, monitor BP
CYP3A4 inhibitors	Increased sildenafil levels	Increased risk of side effects	Dose adjustment may be needed
Rifampin	Reduced sildenafil effectiveness	Lower plasma levels	May require dose increase

Both sildenafil tablets lp 100 mg the suspension and the solution were slightly pink and fruit-flavored. The suspension demonstrated stability for 91 days at both 4°C and 25°C; however, the solution was stable only for 30 days, possibly related to a nonredispersible sediment at the bottom of the container.3 A study by Nahata and colleagues that involved sildenafil citrate tablets (Revatio 20 mg) with a mixture of 1:1 Ora-Sweet and Ora-Plus at 2.5 mg/mL and pH 4.5-4.7 demonstrated stability of 91 days at both 4°C and 25°C. Also studied was a mixture of 1:7 (1% methyl cellulose:simple syrup) at pH 5.1 to 4.9 that also demonstrated stability of 91 days at both 4°C and 25°C.4 Sildenafil citrate (C22H30N6O4S.C6H8O7, MW 666.70) occurs as a white to off-white, crystalline powder that is soluble 3.5 mg/mL in water. It is formulated as tablets equivalent to 25 mg, 50 mg, and 100 mg of sildenafil for oral administration. The tablets also contain microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, lactose, triacetin, and FD&C Blue #2 Aluminum Lake.6,7 Ora-Plus is an oral suspending vehicle that accepts dilution of up to 50% or more with water, flavoring agents, or syrups while still retaining its suspending properties. It has a pH of approximately 4.2 and an osmolality of about 230 mOsm/kg. It is a thixotropic vehicle with a viscosity of approximately 1,000 cps at 25°C.

Sildenafil is sometimes used off-label for other medical conditions.
Continuous use without medical supervision is not recommended.
Follow your provider's instructions for frequency of use.

Ora-Plus contains purified water, microcrystalline cellulose, sodium carboxymethyl cellulose, xanthan gum, carrageenan, sodium phosphate, and citric acid as buffering agents; simethicone as an antifoaming agent; and potassium sorbate and methylparaben as preservatives.8 Ora-Sweet syrup vehicle is a flavoring vehicle for oral extemporaneous preparations. It is flavored with a citrus-berry flavor blend and contains glycerin and sorbitol to prevent cap lock, a problem associated with many syrups. It is buffered to a pH of approximately 4.2 and it has an osmolality of about 3,240 mOsm/kg.